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Brain Cancer treatment details. Chemotherapy. Massachusetts General Hospital, Massachusetts , United States



Survival: 10.4 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Camptosar
Country: United States
   
City/State/Province: Massachusetts
   
Hospital: Massachusetts General Hospital
   
Journal: Link
   
Date: 1/2004

Description:
Patients: This Phase II study involved 18 patients with recurrent malignant gliomas. Of the 18 patients, 12 patients had recurrent glioblastoma multiforme, 5 patients had recurrent anaplastic astrocytoma, and 1 patient had recurrent gliosarcoma.

Treatment: The treatment consisted of administration of the chemotherapy drug, irinotecan.

Toxicity: Toxicities included grade 3-4 diarrhea, grade 5 infection (fatal) in 1 patient, grade 4 neutropenia, and grade 3 respiratory failure and increased intracranial pressure.

Results: Median overall survival for all patients was 10.4 months.

Correspondence: Stuart A. Grossman, MD

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