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Ovarian Cancer treatment details. Chemotherapy. Istituto Nazionale Tumori, Napoli, Italy

Survival: 53.2 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: Italy
City/State/Province: Napoli
Hospital: Istituto Nazionale Tumori
Journal: Link
Date: 9/2011

This phase II study involved patients with stage IC to IV ovarian cancer not previously treated with chemotherapy who were separated into two different treatment groups. Groups A and B consisted of 410 patients each, and both groups had a median age of 57 years.

Patients in groups A were treated with the chemotherapy agents carboplatin and pegylated liposomal doxorubicin. Patients in group B were treated with the chemotherapy agents carboplatin and paclitaxel.

Treatment-related deaths due to bleeding and blood clotting were reported for group A. Also, grade 1-3 nausea, vomiting, and constipation were reported for this group, and 60% of patients reported grade 2 hair loss.

For group B, treatment-related deaths due to septic shock, sudden death, and fever were reported. Grade 1-3 nausea and stomatitis (inflammation of the stomach lining) was also reported for this group.

The median overall survival rates for groups A and B were 61.1 and 53.2 months, respectively. The median progression-free survival rates for groups A and B were 19.0 and 16.8 months, respectively.

This study was partially supported by Schering-Plough Pharmaceuticals.

Correspondence: Dr. Sandro Pignata; email:

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