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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Duke University Medical Center, Durham, NC, United States



Survival: 8.5 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Durham, NC
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 7/2011

Description:
Patients:
This study involved 32 patients with recurrent glioblastoma who had been previously treated with radiation therapy and temozolomide. The median patient age was 56 years and 59% were male.

Treatment:
Patients were treated with the chemotherapy agent temozolomide and the biologic therapy agent bevacizumab.

Toxicities:
There was one reported treatment-related death due to pneumonia. There was also one case of grade 4 pancreatitis. Grade 3 fatigue, diarrhea, and hemorrhoids were also reported.

Results:
The median progression-free survival and overall survival were 3.6 and 8.5 months, respectively.

Support:
This study was supported by Genetech, makers of bevacizumab (trade name: Avastin).

Correspondence: Dr. Annick Desjardins; email: desja002@mc.duke.edu

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