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Brain Cancer treatment details. Chemotherapy. National Cancer Institute, Bethesda, MD, United States



Survival: 7.8 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Bethesda, MD
   
Hospital: National Cancer Institute
   
Journal: Link
   
Date: 5/2011

Description:
Patients:
This phase II study involved 40 patients with recurrent glioblastoma who had received prior treatment. The median patient age was 55 years and 75% were male.

Treatment:
Patients were treated with the chemotherapy agent romidepsin, which interferes with cancer cell DNA replication.

Toxicities:
The most severe reported adverse events were of grade 4 and included fatigue and thrombosis. Also reported were grade 3 neutropenia, lymphopenia, and thrombocytopenia.

Results:
The reported median overall survival was 7.8 months.

Correspondence: Dr. Howard Fine; email: hfine@mail.nih.gov

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