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Colon Cancer treatment details. Biologic therapy. Chemotherapy. National University Hospital, Singapore, Singapore



Survival: 9.5 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Singapore
   
City/State/Province: Singapore
   
Hospital: National University Hospital
   
Journal: Link
   
Date: 4/2011

Description:
Patients:
This study involved 123 metastatic colorectal cancer patients who had been previously treated with irinotecan. The median age was 56 years and 59.3% were male.

Treatment:
Patients were treated with the chemotherapy agent irinotecan and the biologic therapy agent cetuximab, which is a monoclonal antibody that blocks a protein (EGFR) involved in cancer cell growth.

Toxicities:
There was one reported treatment-related death but the specific cause was not given. Otherwise, grade 3-4 diarrhea (13.8% of patients), neutropenia (8.9%), and vomiting (5.7%) were reported.

Results:
The median progression-free and overall survival rates were 2.8 and 9.5 months, respectively.

Support:
This study was supported by the pharmaceutical company Merck.

Correspondence: Dr. Robert Lim; email: robert_lim@nuhs.edu.sg

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