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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Research Institute and Hospital, National Cancer Center, Gyeonggi-do, Korea



Survival: 11.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Korea
   
City/State/Province: Gyeonggi-do
   
Hospital: Research Institute and Hospital, National Cancer Center
   
Journal: Link
   
Date: 11/2010

Description:
Patients:
This phase II study involved 61 patients with extensive-disease small-cell lung cancer who had not previously received chemotherapy. The median age was 65 years and 92% were male.

Treatment:
Patients were treated with the chemotherapy agents irinotecan and cisplatin, and the biological therapy agent simvastatin, which is a statin drug traditionally used as a cholesterol-lowering drug but may also inhibit cancer cell growth.

Toxicities:
There were two reported treatment-related deaths due to infection. Grade 3 diarrhea, anemia, and nausea/vomiting were also reported.

Results:
The median overall survival was 11 months.

Support:
This study was partially supported by CJ Pharmaceutical Co., makers of simvastatin.

Correspondence: Dr. Ji-Youn Han; email: jymama@ncc.re.kr

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