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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. Women's Cancer Care of Seattle, Seattle, WA, United States



Survival: 16.6 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Seattle, WA
   
Hospital: Women's Cancer Care of Seattle
   
Journal: Link
   
Date: 8/2011

Description:
Patients:
This study involved 40 women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer with a median patient age of 58.6 years. All patients had received prior platinum-based chemotherapy.

Treatment:
Patients were treated with the chemotherapy agent topotecan and the biologic therapy agent bevacizumab.

Toxicities:
The most severe adverse events included grade 4 myocaardial ischemia (decreased blood flow to the heart) and pain. Grade 3 high blood pressure and gastrointestinal toxicities were also reported.

Results:
The median overall survival was 16.6 months.

Support:
This study was supported by the pharmaceutical companies Genentech and GlaxoSmithKline.

Correspondence: Dr. Kathryn F. McGonigle; email: kathryn.mcgonigle@nwhsea.org

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