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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Duke University Medical Center, Durham, NC, United States



Survival: 8.3 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Durham, NC
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 10/2011

Description:
Patients:
This phase II study involved 40 glioblastoma patients who had not received prior treatment with bevacizumab. The median patient age was 51 years and 75% were male.

Treatment:
Patients were treated with the chemotherapy drugs carboplatin and irinotecan, as well as the biologic therapy agent bevacizumab.

Toxicities:
One patient died due to treatment-related intestinal perforation. Grade 3-4 blood clots and neutropenia were also reported, as was grade 3 fatigue, infection, and nausea.

Results:
The median overall survival was 8.3 months.

Support:
This study was partially supported by Genentech, makers of bevacizumab.

Correspondence: Dr. David A. Reardon; email: reard003@mc.duke.edu

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