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Brain Cancer treatment details. Biologic therapy. New York Medical College, Vallhalla, New York, United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Vallhalla, New York
   
Hospital: New York Medical College
   
Journal: Link
   
Date: 1/1999

Description:
Patients: This Phase II study involved a total of 16 patients. Twelve patients had glioblastoma multiforme and 4 patients had anaplastic astrocytoma. All patients were previously treated with radiation therapy following surgery.

Treatment: The treatment consisted of the administration of didemnin B. Didemnin B is a natural product derived from a marine invertebrate (Caribbean Tunicate).

Toxicity: Toxicities included grade 4 skin (ulcerating dermatitis), and grade 1 and/or 2 proteinuria, increased LFT’s, hyperglycemia, hypoglycemia, nasea/vomiting, stomatitis, and blood count changes.

Results: There were no responses. Overall survival was not discussed.

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