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Breast Cancer treatment details. Chemotherapy. University General Hospital of Heraklion, Crete, Greece



Survival: 22.4 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: Greece
   
City/State/Province: Crete
   
Hospital: University General Hospital of Heraklion
   
Journal: Link
   
Date: 9/2011

Description:
Patients:
This phase III study involved women with metastatic breast cancer who had previously received chemotherapy. These patients were divided into two separate treatment groups. Group A had 74 patients with a median age of 60 years. Group B also consisted of 74 patients with a median age of 60 years.

Treatment:
Group A was treated with a combination of the chemotherapy agents vinorelbine and gemcitabine. Group B was treated with the chemotherapy agent capecitabine.

Toxicities:
The most severe toxicities in group A were grade 4 neutropenia (5 patients). Grade 3 fatigue (3 patients) was also reported.

The most severe toxicities in group B were one case each of grade 4 neutropenia and allergy. Grade 3 hand-foot skin reaction (4 patients) was also reported.

Results:
The median overall survival for groups A and B was 20.4 and 22.4 months, respectively.

Correspondence: Dr. D. Mavroudis; email: georgsec@med.uoc.gr

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