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Colon Cancer treatment details. Biologic therapy. Memorial Sloan-Kettering Cancer Center, New York, NY, United States



Survival: 4.8 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 7/2010

Description:
Patients:
This phase II study involved 47 previously treated metastatic colorectal cancer patients. The median age was 62 years and 59% were male.

Treatment:
Patients were treated with the biologic therapy agent tremelimumab, which is an anti-CTLA4 monoclonal antibody that promotes attack of cancer cells by the immune system.

Toxicities:
The most severe toxicity was grade 4 thrombocytopenia. Grade 3 diarrhea, fatigue, and colitis were also reported.

Results:
The median progression-free survival was 2.3 months and median overall survival was 4.8 months.

Support:
This study was supported by Pfizer, makers of tremelimumab.

Correspondence: Dr. Ki Y. Chung; email: chungk@mskcc.org

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