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Liver Cancer treatment details. Biologic therapy. Chemotherapy. National Taiwan University Hospital, Taipei, Taiwan Region



Survival: 7.4 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Taiwan Region
   
City/State/Province: Taipei
   
Hospital: National Taiwan University Hospital
   
Journal: Link
   
Date: 7/2010

Description:
Patients:
This phase II study involved 53 patients with advanced hepatocellular carcinoma. The median patient age was 57 years and 89% were male.

Treatment:
Patients were treated with the biologic therapy agent sorafenib (blocks cancer cell growth by targeting tyrosine kinase proteins on the cell surface) and the chemotherapy agent tegafur/uracil.

Toxicities:
The most severe toxicities were grade 4 elevation of the lipase enzyme. Grade 3 fatigue, hand-foot skin reaction, and bleeding were also reported.

Results:
The median progression-free survival was 3.7 months and the median overall survival was 7.4 months.

Support:
This study was partially supported by the pharmaceutical company Bayer HealthCare.

Correspondence: Dr. Chiun Hsu; email: chsu1967@ntu.edu.tw

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