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Liver Cancer treatment details. Biologic therapy. Massachusetts General Hospital, Boston, MA, United States



Survival: 9.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Massachusetts General Hospital
   
Journal: Link
   
Date: 6/2009

Description:
Patients:
This phase II study involved 34 advanced hepatocellular carcinoma patients with a median age of 64 years; 85% were male.

Treatment:
Patients were treated with the biologic therapy agent sunitinib, which is a tyrosine kinase inhibitor that interferes with cancer cell growth.

Toxicities:
There were 2 deaths reported during the early phase of treatment that were reported to be likely related to progression of their cancer. There were also 2 cases of grade 4 thrombocytopenia and 1 case of grade 4 pulmonary embolism. Grade 3 fatigue and anemia were also reported.

Results:
The median progression-free survival was 3.9 months and median overall survival was 9.8 months.

Support:
This study was partially funded by Pfizer, makers of Sutent (brand name for sunitinib).

Correspondence: Dr. Andrew X. Zhu; email: azhu@partners.org

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