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Liver Cancer treatment details. Biologic therapy. The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States

Survival: 15.6 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Houston, TX
Hospital: The University of Texas M. D. Anderson Cancer Center
Journal: Link
Date: 2/2009

This phase II study involved 40 advanced hepatocellular carcinoma patients with a median age of 64 years; 77.5% were male.

Patients were treated with a combination of two biologic therapy agents, bevacizumab and erlotinib (a small molecular inhibitor of epidermal growth factor receptor tyrosine kinase, which is involved in cell growth and survival).

There was one treatment-related death due to gastrointestinal bleeding. Grade 3 acne, delayed wound healing, fatigue, and diarrhea were also reported.

The median overall survival was 15.6 months.

Some of the authors have received funding from Genentech, makers of bevacizumab and erlotinib.

Correspondence: Dr. Melanie B. Thomas; email:

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