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Liver Cancer treatment details. Biologic therapy. The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States



Survival: 15.6 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, TX
   
Hospital: The University of Texas M. D. Anderson Cancer Center
   
Journal: Link
   
Date: 2/2009

Description:
Patients:
This phase II study involved 40 advanced hepatocellular carcinoma patients with a median age of 64 years; 77.5% were male.

Treatment:
Patients were treated with a combination of two biologic therapy agents, bevacizumab and erlotinib (a small molecular inhibitor of epidermal growth factor receptor tyrosine kinase, which is involved in cell growth and survival).

Toxicities:
There was one treatment-related death due to gastrointestinal bleeding. Grade 3 acne, delayed wound healing, fatigue, and diarrhea were also reported.

Results:
The median overall survival was 15.6 months.

Support:
Some of the authors have received funding from Genentech, makers of bevacizumab and erlotinib.

Correspondence: Dr. Melanie B. Thomas; email: thomasmb@musc.edu

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