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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Radiation. Wisconsin Institute for Medical Research, Madison, WI, United States



Survival: 16.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Madison, WI
   
Hospital: Wisconsin Institute for Medical Research
   
Journal: Link
   
Date: 1/2012

Description:
Patients:
This phase III study involved non–small-cell lung cancer patients who were divided into two separate treatment groups. Group A consisted of 275 patients with a median age of 63 years and 62% male. Group B had 271 patients with a median age of 63 years and 60% male.

Treatment:
Patients in group A were treated with radiation and the chemotherapy drugs paclitaxel and carboplatin.
Group B was treated with radiation, paclitaxel, carboplatin, and the biologic therapy agent thalidomide.

Toxicities:
Treatment–related deaths were reported in group A due to thromboembolism (blood clot) and infection.

In group B, treatment-related deaths due to thromboembolism (blood clot), pneumonia, and cardiac ischemia (reduced blood flow).

Results:
The median overall survival rate for groups A and B was 15.3 and 16.0 months, respectively.

Support:
Some of the authors have served as consultants for several pharmaceutical companies.

Correspondence: Dr. Tien Hoang; email: txh@medicine.wisc.edu

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