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Melanoma treatment details. Chemotherapy. Saint John's Health Center, Santa Monica, CA, United States

Survival: 8.6 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: United States
City/State/Province: Santa Monica, CA
Hospital: Saint John's Health Center
Journal: Link
Date: 1/2012

This phase II study involved previously untreated metastatic melanoma patients who were divided into two separate treatment groups. Group A consisted of 71 patients with a median age of 60 years and 70.4% male. Group B had 143 patients with a median age of 60 years and 68.5% male.

Patients in group A were treated with the chemotherapy agents paclitaxel and carboplatin.

Patients in group B were treated with paclitaxel, carboplatin, and the biologic therapy agent bevacizumab.

The most severe toxicities reported for group A were grade 3-4 neutropenia and hemorrhage.

There were 2 deaths possibly related to treatment in group B. Grade 3-4 peripheral neuropathy (nerve disorder), high blood pressure, and neutropenia were also reported.

The median overall survival rate for groups A and B was 8.6 and 12.3 months, respectively.

This study was supported by Genentech, makers of bevacizumab.

Correspondence: Dr. Steven J. O’Day; email:

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