Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. Indiana University, Indianapolis, IN, United States



Survival: 14.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Indianapolis, IN
   
Hospital: Indiana University
   
Journal: Link
   
Date: 12/2011

Description:
Patients:
This phase II study involved 14 women with ovarian cancer or primary peritoneal carcinomatosis who had received prior platinum-based chemotherapy. The median patient age was 52.5 years.

Treatment:
Patients were treated with the chemotherapy agent topotecan and the biologic therapy agent sorafenib, which blocks cancer cell growth by targeting tyrosine kinase proteins on the cell surface.

Toxicities:
The most severe toxicities were of grade 4 and included leukopenia/neutropenia, thrombocytopenia, infection and fatigue. Grade 3 nausea, diarrhea/constipation, and pain were also reported.

Results:
The median overall survival was 14 months.

Support:
The sorafenib drug was provided by Bayer.

Correspondence: Dr. D. Matei; email: dmatei@iupui.edu

E-mail to a Friend Email Physician More Information