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Bladder Cancer treatment details. Chemotherapy. Hormone. Massachusetts General Hospital, Boston, MA, United States



Survival: 9.6 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Hormone
   
Drugs: Pemetrexed
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Massachusetts General Hospital
   
Journal: Link
   
Date: 7/2006

Description:
Patients:
This phase II study involved 47 patients with transitional cell cancer of the urothelium, a type of bladder cancer, who had received prior chemotherapy. The median patient age was 64 years and 80.9% were male.

Treatment:
Patients were treated with the chemotherapy agent pemetrexed. Patients also received prophylactic care with folic acid and B12 vitamins and with the steroid dexamethasone.

Toxicity:
The most severe adverse events were of grade 4 and included leukopenia and neutropenia.

Results:
The reported median overall survival was 9.6 months.

Support:
This study was supported by the pharmaceutical company Eli Lilly.

Correspondence: Dr. Donald S. Kaufman; email: dskaufman@partners.org

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