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Non-Hodgkin's Lymphoma treatment details. Chemotherapy. Hormone. Universitat Koln, Koln, Germany



Survival: 17.9 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Hormone
   
Drugs:
Country: Germany
   
City/State/Province: Koln
   
Hospital: Universitat Koln
   
Journal: Link
   
Date: 4/2011

Description:
Patients:
This phase II study involved 30 patients with aggressive non-Hodgkin’s lymphoma who had previously received chemotherapy. The median patient age was 61.2 years and 40% were male.

Treatment:
Patients were treated with the chemotherapy agents pixantrone, cyclophosphamide, and vincristine, along with the steroid hormone prednisone.

Toxicities:
The most severe adverse events were of grade 4. Grade 3-4 toxicities included neutropenia with fever, anemia, abdominal pain, and heart failure (not reported to have resulted in death).

Results:
The median overall survival was 17.9 months.

Support:
This study was supported by Cell Therapeutics, Inc., makers of pixantrone.

Correspondence: Dr. Andreas Engert; email: a.engert@uni-koeln.de

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