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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Chemotherapy. University Hospitals Case Medical Center, Cleveland, Ohio, United States



Survival: 21.4 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Cleveland, Ohio
   
Hospital: University Hospitals Case Medical Center
   
Journal: Link
   
Date: 8/2009

Description:
Patients:
This study involved 14 patients with non-Hodgkin’s lymphoma who had relapsed after stem cell transplantation. The median patient age was 57 years and 9 were male.

Treatment:
Patients were treated with bryostatin 1, a biologic therapy agent that targets protein kinase C in order to interfere with cancer cell growth, and the chemotherapy agent vincristine.

Toxicities:
The most severe toxicity was one case of grade 4 neutropenia. Grade 3 leukopenia was also reported.

Results:
The median overall survival was 21.4 months.

Correspondence: Dr. Paul M. Barr; email: paul.barr@uhhospitals.org

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