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Colon Cancer treatment details. Chemotherapy. Haukeland University Hospital, Bergen, Norway

Survival: 16.1 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Adrucil
Country: Norway
City/State/Province: Bergen
Hospital: Haukeland University Hospital
Journal: Link
Date: 1/2004

Patients: This Phase II study involved 85 patients with metastatic colorectal cancer.

Treatment: The treatment consisted of three chemotherapy drugs oxaliplatin (eloxatin), fluorouracil (adrucil), and folinic acid (leucovorin).

Toxicity: Neutropenia was the main adverse event, with grade 3 to 4 toxicity in 58% of patients. Febrile neutropenia developed in seven patients. Nonhematologic toxicity consisted mainly of neuropathy (grade 3 in 11 patients and grade 2 in another 27 patients). Other grade 3-4 toxicities included: myocardial ischemia and nausea/vomiting. Nineteen patients were hospitalized because of probable treatment-related toxicity.

Results: The median overall survival was 16.1 months.

Support: This study was partially supported by Sanofi Winthrop. Oxaliplatin is manufactured by Sanofi Winthrop.

Correspondence: H. Sorbye, MD

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