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Brain Cancer treatment details. Biologic therapy. Chemotherapy. The University of Texas MD Anderson Cancer Center, Houston, TX, United States



Survival: 16.6 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, TX
   
Hospital: The University of Texas MD Anderson Cancer Center
   
Journal: Link
   
Date: 11/2011

Description:
Patients:
This phase II trial involved 39 patients with anaplastic glioma. The median patient age was 43 years and 62% were male.

Treatment:
Patients were treated with the chemotherapy agent irinotecan and the biologic therapy agent thalidomide (an antiangiogenic drug that targets tumor blood supply).

Toxicities:
There were 4 treatment-related deaths due to pulmonary embolism, diarrhea/dehydration, and infection. Grade 3-4 neutropenia and fatigue were also reported.

Results:
The median overall survival was 16.6 months.

Support:
This study was supported by the pharmaceutical companies Celgene and Pfizer.

Correspondence: Vinay K. Puduvalli; email: vpuduval@mdanderson.org

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