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Breast Cancer treatment details. Biologic therapy. The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Survival: 11.8 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Houston, TX
Hospital: The University of Texas MD Anderson Cancer Center
Journal: Link
Date: 1/2012

This phase II study involved 45 women with metastatic breast cancer who had received prior chemotherapy. The median age was 50 years.

Patients were treated with the biologic therapy agent R11.4610 (also known as Angiozyme), which is an enzyme that stops the VEGFR protein (involved in tumor growth) from being made.

There was one case of grade 4 jaundice, which was the most severe adverse event reported. Nerve disorders and pain were also reported.

The reported median overall survival was 11.89 months.

This study was supported by Sirna Therapeutics, the makers of Angiozyme.

Correspondence: Dr. Phuong Khanh H. Morrow; email:

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