Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Breast Cancer treatment details. Biologic therapy. Chemotherapy. Karolinska Institutet and University Hospital, Stockholm, Sweden



Survival: 24.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Sweden
   
City/State/Province: Stockholm
   
Hospital: Karolinska Institutet and University Hospital
   
Journal: Link
   
Date: 2/2012

Description:
Patients:
This phase III study involved women with advanced breast cancer who were separated into two separate treatment groups. Group A consisted of 296 patients with a median age of 54 years. Group B had 297 patients with a median age of 56 years.

Treatment:
Patients in group A were treated with the biologic therapy agent sunitinib (a tyrosine kinase inhibitor that targets blood supply to the tumor) and the chemotherapy agent docetaxel.

Group B was treated with docetaxel alone.

Toxicities:
In group A there were 6 treatment-related deaths, the causes of which included heart attack and pulmonary embolism. Fatigue and hand-foot skin reaction were also reported.

The most severe treatment-related toxicities in group B were grade 4 nerve disorders and fatigue.

Results:
The median overall survival for group A was 24.8 months. For group B, the median overall survival was 25.5 months.

Support:
Several of the authors were employed by or received funding from pharmaceutical companies, including Pfizer, the makers of sunitinib.

Correspondence: Dr. Jonas Bergh; email: jonas.bergh@ki.se

E-mail to a Friend Email Physician More Information