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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Salvatore Hospital, L’Aquila, Italy



Survival: 28.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Italy
   
City/State/Province: L’Aquila
   
Hospital: Salvatore Hospital
   
Journal: Link
   
Date: 10/2010

Description:
Patients:
This phase II study involved 50 metastatic colorectal cancer patients with a median age of 63 years; 31 were male.

Treatment:
Patients were treated with a combination of the chemotherapy agents 5-fluorouracil, irinotecan, and oxaliplatin, as well as the biologic therapy agent bevacizumab.

Toxicities:
There was one case of grade 4 liver toxicity, which was the most severe adverse event reported. Grade 3 diarrhea, nausea/vomiting, and mucositis (inflammation of the lining of the GI tract) were also reported.

Results:
The median overall survival in this study was 28 months.

Correspondence: Dr. Enrico Ricevuto; email: enrico.ricevuto@univaq.it

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