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Ovarian Cancer treatment details. Chemotherapy. Cedars-Sinai Medical Center, Los Angeles, CA, United States



Survival: 20.9 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Los Angeles, CA
   
Hospital: Cedars-Sinai Medical Center
   
Journal: Link
   
Date: 2/2012

Description:
Patients:
This study involved women with recurrent ovarian cancer who were separated into two separate treatment groups. Group A had 53 patients with a median age of 59 years. Group B had 55 patients with a median age of 62 years.

Treatment:
Patients in group A were treated with the chemotherapy agent paclitaxel and the biologic therapy agent AMG386, which is an inhibitor of proteins involved in getting a blood supply to the tumor.

Patients in group B were treated with paclitaxel only.

Toxicities:
There was one treatment-related death due to an unspecified cause in group A. Grade 3 or higher nerve effects, blood clotting, and bleeding were also reported.

There were 5 treatment-related deaths due to progressive disease and unspecified causes in group B. Blood clots, fatigue, and abdominal pain were also reported.

Results:
The median overall survival rates for groups A and B were 22.5 and 20.9 months, respectively.

Support:
This study was supported by the pharmaceutical company Amgen, makers of AMG 386.

Correspondence: Dr. Beth Y. Karlan; email: Beth.Karlan@cshs.org

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