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Colon Cancer treatment details. Chemotherapy. Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States



Survival: ?
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Eloxatin
Xeloda
Country: United States
   
City/State/Province: Detroit, Michigan
   
Hospital: Karmanos Cancer Institute, Wayne State University
   
Journal: Link
   
Date: 2/2004

Description:
Patients: This Phase II study involved a total of 48 patients with previously untreated advanced colorectal cancer. (Thirty-eight patients had colon cancer and ten patients had rectal cancer.)

Treatment: The treatment consisted of the chemotherapy drugs capecitabine (xeloda) and oxaliplatin (eloxatin). (Thirteen patients received higher doses than 35 patients.)

Toxicity: One patient who was hospitalized with diarrhea/dehydration later developed sepsis and died. Toxicities included grade 4 deep vein thrombosis and grade 3 diarrhea, vomiting, abdominal pain, dehydration, hypotension, neutropenia, fever, anemia, thrombocytopenia, hand-foot syndrome, neuropathy, fatigue, and mucositis.

Results: Overall survival was not discussed.

Support: This study was supported by Sanofi-Synthelabo. All the authors of this study had received financial compensation from Sanofi-Synthelabo for speaking fees and/or consulting.

Correspondence: Anthony F. Shields, MD

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