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Liver Cancer treatment details. Biologic therapy. National Taiwan University Hospital, Taipei, Taiwan Region



Survival: 6.5 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: Taiwan Region
   
City/State/Province: Taipei
   
Hospital: National Taiwan University Hospital
   
Journal: Link
   
Date: 1/2009

Description:
Patients:
This phase III study involved 150 advanced hepatocellular carcinoma patients who had no prior chemotherapy. The median age was 51 years and 84.7% were male.

Treatment:
Patients were treated with the biologic therapy agent sorafenib, which blocks cancer cell growth by targeting tyrosine kinase proteins on the cell surface.

Toxicities:
The most severe reported treatment-related toxicities were grade 3-4 hand-foot skin reaction, diarrhea, and fatigue.

Results:
Median overall survival was 6.5 months

Support:
This study was supported by Bayer Pharmaceuticals.

Correspondence: Dr. Ann-Lii Cheng; email: alcheng@ntu.edu.tw

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