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Mesothelioma Cancer treatment details. Biologic therapy. Emory University, Atlanta, GA, United States

Survival: 5.0 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Atlanta, GA
Hospital: Emory University
Journal: Link
Date: 1/2009

This phase II study involved 13 previously treated advanced mesothelioma patients with a median age of 73 years; 8 were male.

Patients were treated with the biologic therapy agent belinostat, which is an inhibitor of a protein involved in DNA replication and cancer cell growth.

There was one death due to heart attack that may have been related to treatment. Grade 4 shortness of breath and hypoxia (low oxygen levels in body) were also reported, as was grade 3 fatigue.

The median overall survival was 5 months.

Correspondence: Dr. Suresh S. Ramalingam; email:

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