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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Chemotherapy. Hormone. Centre régional de lutte contre le cancer de Nice, Nice, France



Survival: 29.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Hormone
   
Drugs:
Country: France
   
City/State/Province: Nice
   
Hospital: Centre régional de lutte contre le cancer de Nice
   
Journal: Link
   
Date: 5/2011

Description:
Patients:
This phase II study involved 149 elderly patients with diffuse large B-cell lymphoma (a type of non-Hodgkin’s lymphoma). The median patient age was 83 years (range of 80-95) and 34% were male.

Treatment:
Patients were treated with the biologic therapy agent rituximab (a monoclonal antibody that directs the immune system to attack cancerous B-cells), the chemotherapy agents cyclophosphamide, doxorubicin, and vincristine, and the hormone prednisone.

Toxicities:
There were 12 treatment-related deaths reported. Grade 3-4 thrombocytopenia, neutropenia, and anemia were also reported.

Results:
The median overall survival was 29 months.

Support:
This study was supported by the pharmaceutical company Amgen.

Correspondence: Dr. Frédéric Peyrade; email: frederic.peyrade@nice.fnclcc.fr

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