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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Chemotherapy. Hormone. Immunotherapy. Mayo Clinic and Mayo Foundation, Rochester, MN, United States



Survival: 30.5 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Hormone
Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic and Mayo Foundation
   
Journal: Link
   
Date: 6/2008

Description:
Patients:
This phase II study involved 57 patients with B-cell non-Hodgkin’s lymphoma who had relapsed following prior treatment. The median patient age was 63 years and 67% were male.

Treatment:
Patients were treated with the biologic therapy agent rituximab (a monoclonal antibody that directs the immune system to attack cancerous B-cells), the chemotherapy agents cisplatin and cytosine arabinoside, the hormone dexamethasone, and the immuotherapy agent G-CSF (which stimulates immune cells).

Toxicities:
There was one reported treatment-related death due to infection. Grade 4 neutropenia (68% of patients) and thrombocytopenia (39%) were also reported.

Results:
The median overall survival was 30.5 months.

Correspondence: Dr. Thomas E. Witzig; email: witzig@mayo.edu

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