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Ovarian Cancer treatment details. Chemotherapy. M.D. Anderson Cancer Center Orlando, Orlando, FL, United States

Survival: 57.3 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: United States
City/State/Province: Orlando, FL
Hospital: M.D. Anderson Cancer Center Orlando
Journal: Link
Date: 12/2011

This phase III study involved women with ovarian cancer who were divided into two separate treatment groups. Group A consisted of 417 patients with a median age of 60 years. Group B had 414 patients with a median age of 60 years.

Patients in Group A were treated with the chemotherapy agents gemcitabine and carboplatin.
Patients in Group B were treated with the chemotherapy agents paclitaxel and carboplatin.

There were 2 deaths in Group A due to infection and respiratory failure. In addition, 80.6% of patients had grade 3-4 neutropenia, 40% had grade 3-4 thrombocytopenia, and 27.4 % had grade 3-4 anemia.

There were 3 deaths in Group B due to infection, pneumonia, and pulmonary embolism. In addition, 78.7% of patients had grade 3-4 neutropenia and 51% had grade 2 or higher alopecia.

The median overall survival rates for groups A and B were 43.8 and 57.3 months, respectively.

This study was supported by the pharmaceutical company Eli Lilly.

Correspondence: Dr. Alan N. Gordon; email:

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