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Brain Cancer treatment details. Biologic therapy. The University of Texas MD Anderson Cancer Center, Houston, TX, United States



Survival: 9.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, TX
   
Hospital: The University of Texas MD Anderson Cancer Center
   
Journal: Link
   
Date: 5/2011

Description:
Patients:
This phase II study involved 42 recurrent malignant glioblastoma patients. The median patient age was 55 years and 25 were male.

Treatment:
Patients were treated with the biologic therapy agent aflibercept, which inhibits the effects of specific proteins that promote tumor growth.

Toxicities:
The maximum toxicities were of grade 4 and included hand-foot skin reaction and low oxygen supply in the brain (CNS ischemia). Fatigue, blood clots, and wound healing complications were also reported.

Results:
The median overall survival was 9.0 months.

Support:
Several of the authors work for or receive funding from various pharmaceutical companies.

Correspondence: Dr. John F. de Groot; email: jdegroot@mdanderson.org

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