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Brain Cancer treatment details. Biologic therapy. The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Survival: 9.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Houston, TX
Hospital: The University of Texas MD Anderson Cancer Center
Journal: Link
Date: 5/2011

This phase II study involved 42 recurrent malignant glioblastoma patients. The median patient age was 55 years and 25 were male.

Patients were treated with the biologic therapy agent aflibercept, which inhibits the effects of specific proteins that promote tumor growth.

The maximum toxicities were of grade 4 and included hand-foot skin reaction and low oxygen supply in the brain (CNS ischemia). Fatigue, blood clots, and wound healing complications were also reported.

The median overall survival was 9.0 months.

Several of the authors work for or receive funding from various pharmaceutical companies.

Correspondence: Dr. John F. de Groot; email:

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