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Colon Cancer treatment details. Chemotherapy. Memorial Sloan-Kettering Cancer Center, New York, New York, United States



Survival: 11.7 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Adrucil
Raltitrexed
Country: United States
   
City/State/Province: New York, New York
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 3/2004

Description:
Patients: This Phase I trial involved 71 patients with advanced colorectal cancer.

Treatment: Treatment consisted of two chemotherapy drugs raltitrexed (Tomudex) and 5-fluorouracil (5-FU, adrucil).

Toxicity: One patient developed neutropenic fever and dehydration and had a cardiac arrest and died. Other toxicities included grade 4 neutropenia (64% of patients had grade 3-4 neutropenia), grade 3-4 leukopenia, and grade 4 mucosistis.

Results: Median survival was 11.7 months

Support: One of the study authors is affiliated with AstraZeneca. AstraZeneca markets raltitrexed (Tomudex). AstraZeneca also supplied the raltitrexed for the study.

Correspondence: G.K. Schwartz

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