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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. St. James's University Hospital, Leeds, United Kingdom

Survival: 36.6 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United Kingdom
City/State/Province: Leeds
Hospital: St. James's University Hospital
Journal: Link
Date: 12/2011

This phase 3 study involved women with ovarian cancer who were divided into 2 separate treatment groups. Group A consisted of 764 patients with a median age of 57 years (range of 18-81). Group B also had 764 patients with a median age of 57 years (range of 24-82).

Patients in group A were treated with the chemotherapy agents carboplatin and paclitaxel.

Patients in group B were treated with carboplatin and paclitaxel and the biologic therapy agent bevacizumab.

There was one treatment-related death in group A due to loss of oxygen to the brain. Grade 3 or higher neutropenia was also reported.

There were 4 treatment-related deaths in group B due to brain hemorrhage, sepsis, and gastrointestinal perforation. Grade 3 or higher hypertension and neutropenia were also reported.

The median overall survival for groups A and B was 28.8 and 36.6 months, respectively.

This study was partially supported by the pharmaceutical company Roche.

Correspondence: Dr. Mahesh K.B. Parmar; email:

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