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Liver Cancer treatment details. Biologic therapy. Princess Margaret Hospital, Toronto, ON, Canada



Survival: 11.6 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: Canada
   
City/State/Province: Toronto, ON
   
Hospital: Princess Margaret Hospital
   
Journal: Link
   
Date: 1/2008

Description:
Patients:
This phase II study involved 15 metastatic hepatocellular carcinoma patients who had no prior systemic chemotherapy. The median patient age was 57 years and 93% were male.

Treatment:
Patients were treated with the biological therapy agent SB-715992, which blocks a protein that tumor cells need to divide.

Toxicities:
The most severe treatment-related toxicities included grade 4 granulocytopenia, leukopenia, and neutropenia with fever. Grade 3 diarrhea was also reported.

Results:
The median survival of patients in this study was 11.6 months.

Correspondence: Dr. Jennifer J. Knox; email: jennifer.knox@uhn.on.ca

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