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Liver Cancer treatment details. Biologic therapy. Princess Margaret Hospital, Toronto, ON, Canada

Survival: 11.6 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Canada
City/State/Province: Toronto, ON
Hospital: Princess Margaret Hospital
Journal: Link
Date: 1/2008

This phase II study involved 15 metastatic hepatocellular carcinoma patients who had no prior systemic chemotherapy. The median patient age was 57 years and 93% were male.

Patients were treated with the biological therapy agent SB-715992, which blocks a protein that tumor cells need to divide.

The most severe treatment-related toxicities included grade 4 granulocytopenia, leukopenia, and neutropenia with fever. Grade 3 diarrhea was also reported.

The median survival of patients in this study was 11.6 months.

Correspondence: Dr. Jennifer J. Knox; email:

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