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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Nagoya City University Graduate School of Medical Sciences, Aichi, Japan



Survival: 13.7 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: Japan
   
City/State/Province: Aichi
   
Hospital: Nagoya City University Graduate School of Medical Sciences
   
Journal: Link
   
Date: 3/2012

Description:
Patients:
This study involved 27 patients with relapsed, aggressive CCR4-positive adult T-cell leukemia-lymphoma. The median age was 64 years and 44% of the patients were male.

Treatment:
Patients were treated with the biologic therapy agent KW-0761, an anti-CCR4 monoclonal antibody, which targets cancer cells to be destroyed by the immune system.

Toxicities:
The most severe toxicities were of grade 4 and included lymphopenia and thrombocytopenia. Grade 3 rash and neutropenia were also reported.

Results:
The reported median overall survival was 13.7 months.

Support:
This study was supported by the pharmaceutical company Kyowa Hakko Kirin.

Correspondence: Dr. Takashi Ishida; email: itakashi@med.nagoya-cu.ac.jp

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