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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Nagoya City University Graduate School of Medical Sciences, Aichi, Japan

Survival: 13.7 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: Japan
City/State/Province: Aichi
Hospital: Nagoya City University Graduate School of Medical Sciences
Journal: Link
Date: 3/2012

This study involved 27 patients with relapsed, aggressive CCR4-positive adult T-cell leukemia-lymphoma. The median age was 64 years and 44% of the patients were male.

Patients were treated with the biologic therapy agent KW-0761, an anti-CCR4 monoclonal antibody, which targets cancer cells to be destroyed by the immune system.

The most severe toxicities were of grade 4 and included lymphopenia and thrombocytopenia. Grade 3 rash and neutropenia were also reported.

The reported median overall survival was 13.7 months.

This study was supported by the pharmaceutical company Kyowa Hakko Kirin.

Correspondence: Dr. Takashi Ishida; email:

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