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Brain Cancer treatment details. Biologic therapy. Kyorin University Faculty of Medicine, Tokyo, Japan



Survival: 10.5 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: Japan
   
City/State/Province: Tokyo
   
Hospital: Kyorin University Faculty of Medicine
   
Journal: Link
   
Date: 7/2012

Description:
Patients:
This phase II study involved 31 patients with recurrent malignant glioma previously treated with temozolomide plus radiotherapy. The median age was 54 years; 51.6% were male.

Treatment:
Patients were treated with the biologic therapy agent bevacizumab, a monoclonal antibody against vascular endothelial growth factor that interferes with cancer cell growth.

Toxicities:
There was one reported death due to brain edema (swelling), which may or may not have been related to treatment. Grade 3-4 congestive heart failure and high blood pressure were also reported.

Results:
The median overall survival was 10.5 months.

Support:
This study was supported by the Chugai Pharmaceutical company.

Correspondence: Dr. Motoo Nagane; email: nagane-nsu@umin.ac.jp

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