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Brain Cancer treatment details. Biologic therapy. Kyorin University Faculty of Medicine, Tokyo, Japan

Survival: 10.5 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: Japan
City/State/Province: Tokyo
Hospital: Kyorin University Faculty of Medicine
Journal: Link
Date: 7/2012

This phase II study involved 31 patients with recurrent malignant glioma previously treated with temozolomide plus radiotherapy. The median age was 54 years; 51.6% were male.

Patients were treated with the biologic therapy agent bevacizumab, a monoclonal antibody against vascular endothelial growth factor that interferes with cancer cell growth.

There was one reported death due to brain edema (swelling), which may or may not have been related to treatment. Grade 3-4 congestive heart failure and high blood pressure were also reported.

The median overall survival was 10.5 months.

This study was supported by the Chugai Pharmaceutical company.

Correspondence: Dr. Motoo Nagane; email:

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