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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. Mayo Clinic, Rochester, MN, United States



Survival: 16.1 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic
   
Journal: Link
   
Date: 6/2012

Description:
Patients:
This phase II study involved 40 women with platinum-resistant ovarian and primary peritoneal carcinoma. The median patient age was 59 years.

Treatment:
Patients were treated with the biologic therapy agent flavopiridol (a serine/threonine kinase inhibitor that targets cyclin-dependent kinases and interferes with cell division) and the chemotherapy agent cisplatin.

Toxicities:
The most severe toxicities were of grade 4 and included hypomagnesemia (low levels of magnesium in the blood) and obstruction of the small intestine. Grade 3 neutropenia and thrombosis were also reported.

Results:
The median overall survival was 16.1 months.

Correspondence: Dr. Keith Bible; email: bible.keith@mayo.edu

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