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Ovarian Cancer treatment details. Chemotherapy. University Medical Center Groningen, Groningen, Netherlands



Survival: 34.7 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: Netherlands
   
City/State/Province: Groningen
   
Hospital: University Medical Center Groningen
   
Journal: Link
   
Date: 6/2012

Description:
Patients:
This study involved women with epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas. Patients were divided into two separate treatment groups. Group A consisted of 99 patients with a median age of 61 years. Group B had 97 patients with a median age of 59 years.

Treatment:
Patients in group A were treated with the chemotherapy agents docetaxel and carboplatin.

Patients in group B were treated with docetaxel and carboplatin, as well as the biologic therapy agent celecoxib, which is an inhibitor of the COX-2 protein and works as an anti-inflammatory drug.

Toxicities:
The most severe toxicities in group A were of grade 3-4 and included neutropenia and leucopenia.
The most severe toxicities in group B were of grade 3-4 and included neutropenia, leucopenia, and skin rash.

Results:
The median overall survival rates for groups A and B were 34.7 and 34.3 months, respectively.

Support:
This study was supported by the pharmaceutical companies Sanofi-Aventis and Pfizer.

Correspondence: Dr. A. K. L. Reyners; email: a.k.l.reyners@umcg.nl

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