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Ovarian Cancer treatment details. Chemotherapy. University Medical Center Groningen, Groningen, Netherlands

Survival: 34.3 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: Netherlands
City/State/Province: Groningen
Hospital: University Medical Center Groningen
Journal: Link
Date: 6/2012

This study involved women with epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas. Patients were divided into two separate treatment groups. Group A consisted of 99 patients with a median age of 61 years. Group B had 97 patients with a median age of 59 years.

Patients in group A were treated with the chemotherapy agents docetaxel and carboplatin.

Patients in group B were treated with docetaxel and carboplatin, as well as the biologic therapy agent celecoxib, which is an inhibitor of the COX-2 protein and works as an anti-inflammatory drug.

The most severe toxicities in group A were of grade 3-4 and included neutropenia and leucopenia.
The most severe toxicities in group B were of grade 3-4 and included neutropenia, leucopenia, and skin rash.

The median overall survival rates for groups A and B were 34.7 and 34.3 months, respectively.

This study was supported by the pharmaceutical companies Sanofi-Aventis and Pfizer.

Correspondence: Dr. A. K. L. Reyners; email:

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