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Bladder Cancer treatment details. Biologic therapy. Chemotherapy. University of Vermont, Burlington, VT, United States



Survival: 15.1 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Burlington, VT
   
Hospital: University of Vermont
   
Journal: Link
   
Date: 6/2009

Description:
Patients:
This study involved 54 advanced urothelial tract carcinoma patients who had no previous chemotherapy. The median age was 63.6 years and 80% were male.

Treatment:
Patients were treated with a biologic therapy called gefitinib (an inhibitor of the epidermal growth factor receptor tyrosine kinase) as well as the chemotherapy agents gemcitabine and cisplatin.

Toxicities:
Deaths due to pulmonary embolism, gastrointestinal bleeding, and infection were reported. Grade 4 neutropenia, diarrhea, and fatigue also occurred.

Results:
The median survival time was 15.1 months

Correspondence: Dr. George Philips; email: george.philips@vtmednet.org

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