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Brain Cancer treatment details. Chemotherapy. University of Heidelberg, Heidelberg, Germany



Survival: 8.6 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: Germany
   
City/State/Province: Heidelberg
   
Hospital: University of Heidelberg
   
Journal: Link
   
Date: 7/2012

Description:
This study involved elderly patients with anaplastic astrocytoma or glioblastoma who were divided into two separate treatment groups. Group A had 195 patients with a median age of 72 years (range of 66-84) and 45% were male. Group B had 178 patients with a median age of 71 years (range 66-82) and 49% male.

Treatment:
Patients in group A were treated with the chemotherapy agent temozolomide.
Group B patients were treated with radiotherapy.

Toxicities:
The most severe toxicities in group A were of grade 4 and included infection and blood clot.

The most severe toxicities in group B were of grade 4 and included infection and neurological disorders.

Results:
Median overall survival was 8.6 months in group A and 9.6 months in group B.

Support:
This study was funded by the pharmaceutical companies Merck Sharp and Dohme.

Correspondence: Dr. Wolfgang Wick; email: wolfgang.wick@med.uniheidelberg.de

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