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Breast Cancer treatment details. Hormone. University of California Irvine Medical Center, Orange, CA, United States

Survival: 47.7 months
Toxicity Grade: 5
Treatments: Hormone
Country: United States
City/State/Province: Orange, CA
Hospital: University of California Irvine Medical Center
Journal: Link
Date: 8/2012

This study involved postmenopausal women with previously untreated metastatic breast cancer who were divided into two separate treatment groups. Group A consisted of 345 patients with a median age of 65 years. Group B had 349 patients with a median age of 65 years.

Patients in group A were treated with the hormone therapy agent anastrozole, which inhibits a protein called aromatase and interferes with tumor growth.

Patients in group B were treated with anastrozole and the hormone therapy fulvestrant which inhibits the estrogen receptor to interfere with tumor cell growth.

The most severe toxic effects in group A were of grade 4 and included blood clots, joint pain, thrombocytopenia, and shortness of breath.

There were three treatment-related deaths in group B due to blood clots and heart disorders. Grade 3 flu-like symptoms and joint pain were also reported.

The median overall survival for groups A and B was 41.3 and 47.7 months, respectively.

This study was partially supported by AstraZeneca.

Correspondence: Dr. Rita S. Mehta; email:

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