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Colon Cancer treatment details. Chemotherapy. Hospital Universitario Central de Asturias, Oviedo, Spain



Survival: 11.9 months
   
Toxicity Grade: 3
   
Treatments: Chemotherapy
   
Drugs: Raltitrexed
Country: Spain
   
City/State/Province: Oviedo
   
Hospital: Hospital Universitario Central de Asturias
   
Journal: Link
   
Date: 10/2011

Description:
Patients:
This study involved colorectal cancer patients who had progressed after previous chemotherapy. Patients were separated into two separate treatment groups. Group A had 38 patients, 24 of whom were male, with a median age of 63.5 years. There were 38 patients with a median age of 65 years in group B; 22 of these were male.

Treatment:
Patients in group A were treated with a combination of the chemotherapy agents raltitrexed and gefitinib.

Patients in Group B received the chemotherapy agent raltitrexed alone.

Toxicities:
The most severe toxicities in group A were of grade 3 and included liver enzyme deregulation, anorexia, diarrhea, and weakness.

The most severe toxicity in group B was one grade 4 kidney failure. Grade 3 liver enzyme deregulation, and diarrhea were also reported.

Results:
The median overall survival times for group A and B were 11.9 and 9.6 months, respectively.

Support:
This study was supported by AstraZeneca, makers of raltitrexed (brand name: Tomudex).

Correspondence: Dr. José María Viéitez; email: josemariavieitez@yahoo.es

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