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Liver Cancer treatment details. Biologic therapy. Karmanos Cancer Institute, Detroit, MI, United States



Survival: 9.5 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Detroit, MI
   
Hospital: Karmanos Cancer Institute
   
Journal: Link
   
Date: 5/2012

Description:
Patients:
This study involved 27 patients with advanced hepatocellular cancer with a median age of 60 years; 74% were male.

Treatment:
Patients were treated with a combination of two biologic therapy agents, bevacizumab and erlotinib (a small molecular inhibitor of epidermal growth factor receptor tyrosine kinase, which is involved in cell growth and survival).

Toxicities:
The maximum grade of treatment-related adverse events was 3 and included fatigue, skin rash, and diarrhea.

Results:
The median overall survival time was 9.5 months.

Support:
Erlotinib was provided by OSI Pharmaceuticals, Inc.

Correspondence: Dr. Philip A. Philip; email: philipp@karmanos.org

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