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Lung Cancer treatment details. Biologic therapy. Chemotherapy. Yonsei University College of Medicine, Seoul, Korea



Survival: 13.6 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Korea
   
City/State/Province: Seoul
   
Hospital: Yonsei University College of Medicine
   
Journal: Link
   
Date: 7/2012

Description:
Patients:
This phase II study involved patients with advanced non-small-cell lung cancer with no prior chemotherapy who were divided into four separate treatment groups. Group A had 37 patients with a median age of 59 years; 32 were male. Group B had 36 patients with a median age of 60 years; 35 were male. Group C had 37 patients with a median age of 58 years; 34 were male. Group D had 36 patients with a median age of 56 years; 33 were male.

Treatment:
Patients in group A were treated with a combination of the chemotherapy agents irinotecan and cisplatin.
Patients in group B were treated with a combination of the chemotherapy agents irinotecan and cisplatin, as well as the biologic therapy agent called isosorbide-5-mononitrate (a drug that acts to dilate the blood vessels).
Patients in group C were treated with a combination of the chemotherapy agents irinotecan and capecitabine.
Patients in group D were treated with a combination of the chemotherapy agents irinotecan and capecitabine, as well as the biologic therapy agent called isosorbide-5-mononitrate (a drug that acts to dilate the blood vessels).

Toxicities:
The most severe treatment-related toxicities in group A were of grade 4. Grade 3-4 effects included neutropenia (60% of patients), anemia (27%), and diarrhea (13%). Grade 1-2 alopecia and nausea/vomiting were also experienced by the majority of patients.

The most severe treatment-related toxicities in group B were of grade 4. Grade 3-4 effects included neutropenia (56% of patients), neutropenia with fever (11%), and anemia (11%). Grade 1-2 alopecia and nausea/vomiting were also experienced by the majority of patients.

The most severe treatment-related toxicities in group C were of grade 4. Grade 3-4 effects included neutropenia (27% of patients) and diarrhea (11%). Grade 1-2 alopecia and nausea/vomiting were also experienced by the majority of patients.

The most severe treatment-related toxicities in group D were of grade 4. Grade 3-4 effects included neutropenia (17% of patients) and diarrhea (6%). Grade 1-2 alopecia and nausea/vomiting were also experienced by the majority of patients.

Results:
The median overall survival times for groups A, B, C, and D were 14.5, 13.0, 16.0, and 13.6 months, respectively.

Correspondence: Dr. J. S. Lee; email: jslee@ncc.re.kr

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