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Mesothelioma Cancer treatment details. Biologic therapy. University of Chicago, Chicago, IL, United States



Survival: 4.4 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Chicago, IL
   
Hospital: University of Chicago
   
Journal: Link
   
Date: 10/2012

Description:
Patients:
This phase II study involved 51 patients with malignant mesothelioma. The median patient age was 64 years and 84% were male.

Treatment:
Patients were treated with the biologic therapy agent cediranib, which is a tyrosine kinase inhibitor of VEGF receptors and interferes with maintaining the blood supply to tumors.

Toxicities:
The most severe toxicities were of grade 4 and included fatigue and blood clotting. Grade 3 diarrhea was also reported.

Results:
The median overall survival was 4.4 months.

Support:
One of the authors has acted as a paid consultant for AstraZeneca, makers of cediranib.

Correspondence: Dr. Hedy L. Kindler; email: hkindler@medicine.bsd.uchicago.edu

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