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Mesothelioma Cancer treatment details. Biologic therapy. University of California, San Francisco, CA, United States



Survival: 9.7 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: San Francisco, CA
   
Hospital: University of California
   
Journal: Link
   
Date: 10/2010

Description:
Patients:
This phase II study involved 51 malignant mesothelioma patients, 70% of whom were male. The median patient age was 69 years.

Treatment:
Patients were treated with the biologic therapy agent sorafenib, which inhibits the receptor for the VEGF protein and subsequently inhibits blood supply to the tumor.

Toxicities:
The most severe toxicity was grade 4 fatigue. Grade 3 rash and shortness of breath were also reported.

Results:
The median overall survival was 9.7 months.

Correspondence: Dr. Pasi A. Janne; email: pjanne@partners.org

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