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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. The Royal Marsden Hospital, Surrey, United Kingdom



Survival: 28.2 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United Kingdom
   
City/State/Province: Surrey
   
Hospital: The Royal Marsden Hospital
   
Journal: Link
   
Date: 9/2012

Description:
Patients:
This phase II study involved 74 women with previously treated ovarian cancer. The median age was 58.1 years.

Treatment:
Patients were treated with a combination of the chemotherapy agents carboplatin and either paclitaxel or gemcitabine. They were also treated with the biologic therapy agent called pertuzumab, a humanized monoclonal antibody targeting human epidermal growth factor receptor that works to interfere with tumor growth.

Toxicities:
There was one treatment-related death due to an unspecified cause. Grade 3-4 neutropenia, thrombocytopenia, diarrhea, and fatigue were also reported.

Results:
The median overall survival was 28.2 months.

Support:
This study was funded by the pharmaceutical company F. Hoffmann-La Roche.

Correspondence: Dr. S. B. Kaye; email: stan.kaye@rmh.nhs.uk

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